Tenoroc summons Dr Toxic in Carnival City to make all the Street Kids sick and Roxie is horribly sick and Lightning too. Matt has no choice but to free Igor so that he can help them defeat Dr Toxic and save Roxie.
Tenoroc has summoned Dr Toxic to poison the Street Kids with different kind of illnesses with his sick gun. When Matt arrives he remembers the movie The Hospital of Dr Toxic. After the fight Roxie and Lightning get hit with the Pox virus. Roxie and Lightning have blue and red spots, then their tongues turn green and finally a high temperature, Gomez and the Business Man say that if they are not cured in 24 hours they will die. Matt and Gomez find that the only antidote is the frozen frogs but with Dr Toxic they will need a distraction to do it. So Matt releases Igor and says that if they don't get the frozen frogs in time Roxie and Lightning are done for. Igor fights the doctor and Matt and Gomez get the antidote and use it to defeat Dr Toxic .Then Matt instead of booking him he asks if he wants to join their team. So it continues.